![]() It is also used in the treatment of polycystic ovary syndrome (PCOS). Metformin can be used alone, or in combination with other medicines for treating type 2 diabetes. ![]() Metformin Hydrochloride (normal Immediate Release) is available in strengths of 2. Glycomet Tablets manufactured by USV Limited . The terms XR and SR are equivalent and refer to the same type of product. There is no difference in effectiveness between the two preparations, but the XR version was introduced mainly to counteract the most common gastrointestinal side effects. It prevents weight gain unlike other anti- diabetic drugs. Metformin is also used in treatment for polycystic ovary syndrome (PCOS), a condition frequently associated with insulin resistance. Women with glucose intolerance have mainly shown improvement, when put on Metformin for treating PCOS. ![]() ![]() Galvumet 50 mg/1000 mg Tablets is a brand of medicine containing the active ingredient vildagliptin - metformin hydrochloride. Find out about side effects, who can. I also take metformin 1000 mg and high blood pressure meds but i dont take them like i should and my sugars are high around the 200 Weight loss with PCOS can feel virtually impossible! There are a number of factors that make losing weight with PCOS really difficult. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. Diabetes Prevention Program Research Group*. Metformin for PCOS & Pregnancy. This page has a simple goal -- to provide journal abstracts regarding metformin use for infertility, specifically PCOS, and abstracts. ![]() Exermet XR Tablets (Metformin HCl SR)and Glycomet Tablets (Metformin Hydrochloride) – Dosage. There is no fixed dosage for the management of hyperglycemia in diabetes mellitus with Metformin (Glycomet tablets) or Metformin SR (Exermet XR Tablets ). The dosage of Metformin HCl must be individualized carefully based on patient response and tolerance. The recommended dosage of Metformin tablets is given below: Adults dosage for Glycomet Tablets The initial dosage of Glycomet tablets is 5. Dosage increases should be made in increments of 5. Adult Dosage for Metformin SR (Exermet XR tablets): The initial dose for Metformin SR is 5. The dose can be gradually increased to the maximum of 2 gm daily in divided doses. Drug Class and Mechanism. Metformin reduces elevated blood glucose levels, predominantly by improving hepatic and peripheral tissue sensitivity to insulin without affecting the secretion of this hormone. Metformin HCl increases glucose utilization and reduces glucose production. Metformin reduces glucose production by the liver (hepatic gluconeogenesis). Glucose production in liver increases by three times in type 2 diabetes patients, which is reduced to one third by Metformin. Metformin also activates AMP- activated protein kinase (AMPK), which leads to an inhibitory effect on the production of glucose by liver cells. AMPK activity also increases in skeletal muscle on administration of Metformin, it is known to effect GLUT4 deployment which results in insulin- independent glucose uptake. It also increases fatty acid oxidation and decreases intestinal absorption of glucose. Increased peripheral utilization of glucose is due to improved insulin binding to insulin receptors. A risk of lactic acidosis is negligible provided the contraindications, perticularly renal failure are respected. What to do in Case You Miss a Dose of Glycomet Tablets. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take the missed dose as soon as you remember (with food),and then go back to taking your tablets as you would normally. Do not take a double dose to make up for the dose you missed. Keep away from children and pets. Warnings and Precautions to be taken when using Metformin Tablets. Before using Glycomet (Metformin tablets) or Exermet XR (Metformin XR tablets) please inform your doctor all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies. When it occurs, it is fatal in approximately 5. Lactic acidosis is a medical emergency and must be treated in hospital immediately. The risk of lactic acidosis increases with the degree of renal dysfunction, liver dysfunction and the patient's age. Stop taking Metformin and consult a physician right away, if you develop any of the following symptoms : unusual tiredness, dizziness, severe drowsiness, chills, blue /cold skin, muscle pain, difficult breathing, slow/irregular heartbeat, stomach pain with nausea, vomiting, or diarrhoea. Heart failure: Type 2 diabetic patients with heart failure are at an increased risk of hypoperfusion and possible renal insufficiency. Renal insufficiency is a risk factor for systemic accumulation of Metformin and consequently lactic acidosis. Therefore, Metformin should be stopped at least 4. Monitoring Renal Function: Metformin is known to be substantially excreted by the kidney and the risk of Metformin accumulation and lactic acidosis increases with the degree of impairment of renal function. Before initiation of Metformin therapy and at least annually thereafter, renal function should be assessed and verified as normal. Surgical Procedures: Metformin therapy should be temporarily suspended for any surgical procedure (except minor procedures not associated with restricted intake of food and fluids) and should be not restarted till the patient's oral intake has resumed and renal function has been evaluated as normal. Alcohol Intake: Alcohol is known to potentiate the effect of Metformin on lactate metabolism. Patients, therefore, should be warned against excessive alcohol intake, acute or chronic, while receiving Metformin. Since it is important to achieve strict normoglycaemia during pregnancy, Metformin should be replaced by insulin. Recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, there is a consensus among experts that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible. Use in Lactation (Breastfeeding) Since Metformin is excreted in milk, caution should be exercised in such patients, and a decision should be made whether to discontinue breastfeeding (nursing) or to discontinue Glycomet, taking into account the importance of the drug to the mother. Especially the risk of developing lactic acidosis is increased. The dosage must be monitored. Cephalexin: Increases the serum concentration of Metformin. Monitoring simultaneous administration is recommended. Cimetidine: Increases the serum concentration of Metformin. It is advised to consider therapy modification. Corticosteroids (orally inhaled): Diminish the hypoglycaemic effect of metformin. Dose modification is recommended. Corticosteroids (Systemic): Diminish the hypoglycemic effect of Metformin. Dose modification is recommended. Dalfampridine: Increases the serum concentration of Metformin. Dose modification is thus recommended. Dofetlide: Metformin may increase the serum concentration of Dofetilide. Therapy modification is recommended. Glycopyrrolate: May increase the serum concentration of Metformin. Dosage needs to be monitored. The therapy needs to be monitored. Pegvisomant: Enhances the hypoglycaemic effect of Metformin. The therapy needs monitoring. Somatropin: May diminish the hypoglycaemic effect of Metformin. Therapy modification is recommended. Thiazide Diuretics: Diminishes the therapeutic effect of Metformin. Dose modification is recommended. Trospium: Metformin may decrease the serum concentration of Trospium. Dosage needs modification. Significant renal impairment (serum creatinine levels greater or equal to 1. L (males), and greater or equal to 1. L (females) or abnormal creatinine clearance). Severe hepatic dysfunction. Excessive alcohol intake either acute or chronic. Cardiovascular collapse and in disease states associated with hypoxemia e. During stress conditions e. Patients with a history of lactic acidosis irrespective of the precipitating factors. The XR version (Extended Release , Sustained Release or SR Version) is available in pills of 5. October 2. 01. 3. Customers who bought this product bought also the following products.
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